About Hematopoietic lineage cell-specific protein
Hematopoietic lineage cell-specific protein (HCLS1) is a protein
from Homo sapiens identified by UniProt accession
P14317, 486 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Hematopoietic lineage cell-specific protein |
|---|
| UniProt accession | P14317 |
|---|
| Gene | HCLS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 486 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.36
- mean reticulocyte volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.22
- Red cell distribution width · score 0.18
- alkaline phosphatase measurement · score 0.14
- inflammatory bowel disease · score 0.14
- arterial stiffness measurement · score 0.10
- platelet count · score 0.09
- asthma · score 0.07
- combined immunodeficiency with skin granulomas · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14317-F1 | alphafold | PREDICTED | 63.60 | — |
Amino-acid sequence (486 residues)
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN YVKLLE
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