Farnesyl pyrophosphate synthase (FDPS)

About Farnesyl pyrophosphate synthase

Farnesyl pyrophosphate synthase (FDPS) is a protein from Homo sapiens identified by UniProt accession P14324, 419 residues long. MolForge cross-references it against 0 known binders and 212 disease associations.

Target properties

Protein name	Farnesyl pyrophosphate synthase
UniProt accession	P14324
Gene	FDPS
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (9)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (212)

Diseases linked to this target (Open Targets).

disseminated superficial actinic porokeratosis · score 0.62
osteoporosis · score 0.61
postmenopausal osteoporosis · score 0.60
multiple myeloma · score 0.60
osteitis deformans · score 0.60
prostate carcinoma · score 0.60
metastasis · score 0.60
prostate cancer · score 0.60
breast cancer · score 0.60
Osteopenia · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14324-F1	alphafold	PREDICTED	85.38	—

Amino-acid sequence (419 residues)

MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW CQAWTEEPRA LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG HPEIGDAIAR LKEVLEYNAI GGKYNRGLTV VVAFRELVEP RKQDADSLQR AWTVGWCVEL LQAFFLVADD IMDSSLTRRG QICWYQKPGV GLDAINDANL LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD LLTAPQGNVD LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ ILKENYGQKE AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA PLPPAVFLGL ARKIYKRRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards