Zinc finger protein RFP (TRIM27)

About Zinc finger protein RFP

Zinc finger protein RFP (TRIM27) is a protein from Homo sapiens identified by UniProt accession P14373, 513 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	Zinc finger protein RFP
UniProt accession	P14373
Gene	TRIM27
Organism	Homo sapiens
Length	513 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

tuberculosis · score 0.37
papillary thyroid carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
thyroid gland oncocytic adenoma · score 0.37
Thyroid Gland Oncocytic Follicular Carcinoma · score 0.37
hepatocellular carcinoma · score 0.30
lung carcinoma · score 0.29
squamous cell lung carcinoma · score 0.29
lung adenocarcinoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14373-F1	alphafold	PREDICTED	88.34	—

Amino-acid sequence (513 residues)

MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR SREHRGHSVL PLEEAVEGFK EQIQNQLDHL KRVKDLKKRR RAQGEQARAE LLSLTQMERE KIVWEFEQLY HSLKEHEYRL LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ QQPTRELLQD IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN PERFNLFPCV LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS APQNGFWAVS LWYGKEYWAL TSPMTALPLR TPLQRVGIFL DYDAGEVSFY NVTERCHTFT FSHATFCGPV RPYFSLSYSG GKSAAPLIIC PMSGIDGFSG HVGNHGHSME TSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards