About Phospholipase A2, membrane associated
Phospholipase A2, membrane associated (PLA2G2A) is a protein
from Homo sapiens identified by UniProt accession
P14555, 144 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Phospholipase A2, membrane associated |
|---|
| UniProt accession | P14555 |
|---|
| Gene | PLA2G2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 144 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (208)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- phospholipase A2, membrane associated measurement · score 0.35
- protein measurement · score 0.34
- familial colorectal cancer · score 0.33
- breast adenocarcinoma · score 0.21
- lung adenocarcinoma · score 0.19
- acute coronary syndrome · score 0.15
- squamous cell lung carcinoma · score 0.14
- coronary artery disease · score 0.10
- cutaneous melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14555-F1 | alphafold | PREDICTED | 90.97 | — |
Amino-acid sequence (144 residues)
MKTLLLLAVI MIFGLLQAHG NLVNFHRMIK LTTGKEAALS YGFYGCHCGV GGRGSPKDAT DRCCVTHDCC YKRLEKRGCG TKFLSYKFSN SGSRITCAKQ DSCRSQLCEC DKAAATCFAR NKTTYNKKYQ YYSNKHCRGS TPRC
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