Neutrophil cytosol factor 1 (NCF1)

About Neutrophil cytosol factor 1

Neutrophil cytosol factor 1 (NCF1) is a protein from Homo sapiens identified by UniProt accession P14598, 390 residues long. MolForge cross-references it against 0 known binders and 324 disease associations.

Target properties

Protein name	Neutrophil cytosol factor 1
UniProt accession	P14598
Gene	NCF1
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (324)

Diseases linked to this target (Open Targets).

chronic granulomatous disease · score 0.64
neurodegenerative disease · score 0.36
Rare familial disorder with hypertrophic cardiomyopathy · score 0.34
hypertrophic cardiomyopathy 4 · score 0.34
systemic lupus erythematosus · score 0.29
breast adenocarcinoma · score 0.25
Crohn's disease · score 0.24
autoimmune disease · score 0.24
C-reactive protein measurement · score 0.20
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14598-F1	alphafold	PREDICTED	82.60	—

Amino-acid sequence (390 residues)

MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKTLKEMFPI EAGAINPENR IIPHLPAPKW FDGQRAAENR QGTLTEYCST LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYL MPKDGKSTAT DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGWWFCQMKA KRGWIPASFL EPLDSPDETE DPEPNYAGEP YVAIKAYTAV EGDEVSLLEG EAVEVIHKLL DGWWVIRKDD VTGYFPSMYL QKSGQDVSQA QRQIKRGAPP RRSSIRNAHS IHQRSRKRLS QDAYRRNSVR FLQQRRRQAR PGPQSPGSPL EEERQTQRSK PQPAVPPRPS ADLILNRCSE STKRKLASAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards