G2/mitotic-specific cyclin-B1 (CCNB1)

About G2/mitotic-specific cyclin-B1

G2/mitotic-specific cyclin-B1 (CCNB1) is a protein from Homo sapiens identified by UniProt accession P14635, 433 residues long. MolForge cross-references it against 0 known binders and 418 disease associations.

Target properties

Protein name	G2/mitotic-specific cyclin-B1
UniProt accession	P14635
Gene	CCNB1
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (418)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
lung adenocarcinoma · score 0.30
endometrial cancer · score 0.29
breast adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
esophageal cancer · score 0.27
squamous cell lung carcinoma · score 0.25
hepatocellular carcinoma · score 0.13
neoplasm · score 0.11
protein measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14635-F1	alphafold	PREDICTED	76.55	—

Amino-acid sequence (433 residues)

MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS ALVQDLAKAV AKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards