Homeobox protein Hox-B3 (HOXB3)

About Homeobox protein Hox-B3

Homeobox protein Hox-B3 (HOXB3) is a protein from Homo sapiens identified by UniProt accession P14651, 431 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Homeobox protein Hox-B3
UniProt accession	P14651
Gene	HOXB3
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
hip bone mineral density · score 0.27
hip bone size · score 0.23
endometrial cancer · score 0.23
breast adenocarcinoma · score 0.22
grip strength measurement · score 0.22
body mass index · score 0.22
smoking status measurement · score 0.18
serum urea measurement · score 0.16
dentures · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14651-F1	alphafold	PREDICTED	56.60	—

Amino-acid sequence (431 residues)

MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards