Homeobox protein Hox-B1 (HOXB1)

About Homeobox protein Hox-B1

Homeobox protein Hox-B1 (HOXB1) is a protein from Homo sapiens identified by UniProt accession P14653, 301 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Homeobox protein Hox-B1
UniProt accession	P14653
Gene	HOXB1
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

Congenital hereditary facial paralysis with variable hearing loss · score 0.63
neurodegenerative disease · score 0.46
congenital hereditary facial paralysis-variable hearing loss syndrome · score 0.37
FEV/FVC ratio · score 0.30
cortical surface area measurement · score 0.24
genetic disorder · score 0.19
insomnia measurement · score 0.17
head and neck squamous cell carcinoma · score 0.15
motion sickness · score 0.05
Joubert syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14653-F1	alphafold	PREDICTED	60.65	—

Amino-acid sequence (301 residues)

MDYNRMNSFL EYPLCNRGPS AYSAHSAPTS FPPSSAQAVD SYASEGRYGG GLSSPAFQQN SGYPAQQPPS TLGVPFPSSA PSGYAPAACS PSYGPSQYYP LGQSEGDGGY FHPSSYGAQL GGLSDGYGAG GAGPGPYPPQ HPPYGNEQTA SFAPAYADLL SEDKETPCPS EPNTPTARTF DWMKVKRNPP KTAKVSEPGL GSPSGLRTNF TTRQLTELEK EFHFNKYLSR ARRVEIAATL ELNETQVKIW FQNRRMKQKK REREEGRVPP APPGCPKEAA GDASDQSTCT SPEASPSSVT S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards