About Solute carrier family 2, facilitated glucose transporter member 4
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) is a protein
from Homo sapiens identified by UniProt accession
P14672, 509 residues long.
MolForge cross-references it against 0 known binders and
375 disease associations.
Target properties
| Protein name | Solute carrier family 2, facilitated glucose transporter member 4 |
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| UniProt accession | P14672 |
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| Gene | SLC2A4 |
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| Organism | Homo sapiens |
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| Length | 509 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (375)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.50
- serum alanine aminotransferase measurement · score 0.27
- systolic blood pressure · score 0.24
- aspartate aminotransferase measurement · score 0.24
- diastolic blood pressure · score 0.23
- Parkinson disease · score 0.22
- lysosomal storage disease · score 0.22
- neurodegenerative disease · score 0.22
- Alzheimer disease · score 0.22
- multiple sclerosis · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14672-F1 | alphafold | PREDICTED | 88.25 | — |
Amino-acid sequence (509 residues)
MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNETW LGRQGPEGPS SIPPGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLVNNVLAV LGGSLMGLAN AAASYEMLIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILIAQVL GLESLLGTAS LWPLLLGLTV LPALLQLVLL PFCPESPRYL YIIQNLEGPA RKSLKRLTGW ADVSGVLAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL SGINAVFYYS TSIFETAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM AVAGFSNWTS NFIIGMGFQY VAEAMGPYVF LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS AAFHRTPSLL EQEVKPSTEL EYLGPDEND
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