About Interleukin-1 receptor type 1
Interleukin-1 receptor type 1 (IL1R1) is a protein
from Homo sapiens identified by UniProt accession
P14778, 569 residues long.
MolForge cross-references it against 0 known binders and
812 disease associations.
Target properties
| Protein name | Interleukin-1 receptor type 1 |
|---|
| UniProt accession | P14778 |
|---|
| Gene | IL1R1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 569 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (812)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.54
- Ascending aortic dissection · score 0.45
- pericarditis · score 0.44
- fibrinogen measurement · score 0.42
- COVID-19 · score 0.40
- blood protein measurement · score 0.39
- C-reactive protein measurement · score 0.39
- immune system disease · score 0.39
- serum alanine aminotransferase measurement · score 0.37
- vital capacity · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14778-F1 | alphafold | PREDICTED | 83.89 | — |
Amino-acid sequence (569 residues)
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ LLSPATKEKL QREAHVPLG
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