About Interleukin-2 receptor subunit beta
Interleukin-2 receptor subunit beta (IL2RB) is a protein
from Homo sapiens identified by UniProt accession
P14784, 551 residues long.
MolForge cross-references it against 0 known binders and
593 disease associations.
Target properties
| Protein name | Interleukin-2 receptor subunit beta |
|---|
| UniProt accession | P14784 |
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| Gene | IL2RB |
|---|
| Organism | Homo sapiens |
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| Length | 551 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (593)
Diseases linked to this target (Open Targets).
- Immunodeficiency syndrome with autoimmunity · score 0.66
- metastatic melanoma · score 0.53
- neoplasm · score 0.51
- kidney cancer · score 0.51
- neurodegenerative disease · score 0.49
- renal cell carcinoma · score 0.48
- Sezary's disease · score 0.47
- Cutaneous T-cell lymphoma · score 0.47
- mycosis fungoides · score 0.47
- tuberculosis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14784-F1 | alphafold | PREDICTED | 64.63 | — |
Amino-acid sequence (551 residues)
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL V
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