About Cytochrome c oxidase subunit 6B1
Cytochrome c oxidase subunit 6B1 (COX6B1) is a protein
from Homo sapiens identified by UniProt accession
P14854, 86 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Cytochrome c oxidase subunit 6B1 |
|---|
| UniProt accession | P14854 |
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| Gene | COX6B1 |
|---|
| Organism | Homo sapiens |
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| Length | 86 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 7 · score 0.70
- neurodegenerative disease · score 0.55
- cytochrome-c oxidase deficiency disease · score 0.46
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.43
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.43
- mitochondrial disease · score 0.37
- Isolated cytochrome C oxidase deficiency · score 0.37
- squamous cell lung carcinoma · score 0.18
- lung adenocarcinoma · score 0.18
- genetic disorder · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14854-F1 | alphafold | PREDICTED | 95.03 | — |
Amino-acid sequence (86 residues)
MAEDMETKIK NYKTAPFDSR FPNQNQTRNC WQNYLDFHRC QKAMTAKGGD ISVCEWYQRV YQSLCPTSWV TDWDEQRAEG TFPGKI
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