About POU domain, class 2, transcription factor 1
POU domain, class 2, transcription factor 1 (POU2F1) is a protein
from Homo sapiens identified by UniProt accession
P14859, 743 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | POU domain, class 2, transcription factor 1 |
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| UniProt accession | P14859 |
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| Gene | POU2F1 |
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| Organism | Homo sapiens |
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| Length | 743 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.38
- blood protein measurement · score 0.30
- body mass index · score 0.30
- adult onset asthma · score 0.30
- neurodegenerative disease · score 0.28
- eosinophil percentage of leukocytes · score 0.28
- neutrophil count · score 0.27
- eosinophil count · score 0.26
- leukocyte count · score 0.25
- thyroid gland adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14859-F1 | alphafold | PREDICTED | 49.11 | — |
Amino-acid sequence (743 residues)
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ NSLFTVASAS GAASTTTTAS KAQ
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