About Heterogeneous nuclear ribonucleoprotein L
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) is a protein
from Homo sapiens identified by UniProt accession
P14866, 589 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein L |
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| UniProt accession | P14866 |
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| Gene | HNRNPL |
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| Organism | Homo sapiens |
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| Length | 589 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- oral squamous cell carcinoma · score 0.08
- urinary bladder carcinoma · score 0.08
- pachyonychia congenita · score 0.07
- neoplasm · score 0.05
- pancreatic neoplasm · score 0.05
- hepatocellular carcinoma · score 0.05
- platelet count · score 0.04
- platelet crit · score 0.03
- head and neck squamous cell carcinoma · score 0.03
- cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14866-F1 | alphafold | PREDICTED | 73.38 | — |
Amino-acid sequence (589 residues)
MSRRLLPRAE KRRRRLEQRQ QPDEQRRRSG AMVKMAAAGG GGGGGRYYGG GSEGGRAPKR LKTDNAGDQH GGGGGGGGGA GAAGGGGGGE NYDDPHKTPA SPVVHIRGLI DGVVEADLVE ALQEFGPISY VVVMPKKRQA LVEFEDVLGA CNAVNYAADN QIYIAGHPAF VNYSTSQKIS RPGDSDDSRS VNSVLLFTIL NPIYSITTDV LYTICNPCGP VQRIVIFRKN GVQAMVEFDS VQSAQRAKAS LNGADIYSGC CTLKIEYAKP TRLNVFKNDQ DTWDYTNPNL SGQGDPGSNP NKRQRQPPLL GDHPAEYGGP HGGYHSHYHD EGYGPPPPHY EGRRMGPPVG GHRRGPSRYG PQYGHPPPPP PPPEYGPHAD SPVLMVYGLD QSKMNCDRVF NVFCLYGNVE KVKFMKSKPG AAMVEMADGY AVDRAITHLN NNFMFGQKLN VCVSKQPAIM PGQSYGLEDG SCSYKDFSES RNNRFSTPEQ AAKNRIQHPS NVLHFFNAPL EVTEENFFEI CDELGVKRPS SVKVFSGKSE RSSSGLLEWE SKSDALETLG FLNHYQMKNP NGPYPYTLKL CFSTAQHAS
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