About Aspartate--tRNA ligase, cytoplasmic
Aspartate--tRNA ligase, cytoplasmic (DARS1) is a protein
from Homo sapiens identified by UniProt accession
P14868, 501 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Aspartate--tRNA ligase, cytoplasmic |
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| UniProt accession | P14868 |
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| Gene | DARS1 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (130)
Diseases linked to this target (Open Targets).
- hypomyelination with brain stem and spinal cord involvement and leg spasticity · score 0.76
- neutrophil count · score 0.35
- eosinophil count · score 0.33
- monocyte count · score 0.31
- leukocyte count · score 0.31
- myeloid white cell count · score 0.28
- Abnormal brain morphology · score 0.27
- breast milk measurement · score 0.26
- serum metabolite measurement · score 0.20
- low density lipoprotein cholesterol measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14868-F1 | alphafold | PREDICTED | 93.34 | — |
Amino-acid sequence (501 residues)
MPSASASRKS QEKPREIMDA AEDYAKERYG ISSMIQSQEK PDRVLVRVRD LTIQKADEVV WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ MVKFAANINK ESIVDVEGVV RKVNQKIGSC TQQDVELHVQ KIYVISLAEP RLPLQLDDAV RPEAEGEEEG RATVNQDTRL DNRVIDLRTS TSQAVFRLQS GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF KNNAYLAQSP QLYKQMCICA DFEKVFSIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH EVMEEIADTM VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE ALAMLREAGV EMGDEDDLST PNEKLLGHLV KEKYDTDFYI LDKYPLAVRP FYTMPDPRNP KQSNSYDMFM RGEEILSGAQ RIHDPQLLTE RALHHGIDLE KIKAYIDSFR FGAPPHAGGG IGLERVTMLF LGLHNVRQTS MFPRDPKRLT P
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