Protein C-ets-1 (ETS1)

About Protein C-ets-1

Protein C-ets-1 (ETS1) is a protein from Homo sapiens identified by UniProt accession P14921, 441 residues long. MolForge cross-references it against 0 known binders and 661 disease associations.

Target properties

Protein name	Protein C-ets-1
UniProt accession	P14921
Gene	ETS1
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (661)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.52
type 2 diabetes mellitus · score 0.51
psoriasis · score 0.51
platelet count · score 0.50
leukocyte count · score 0.49
lymphocyte percentage of leukocytes · score 0.49
neutrophil count · score 0.48
intraocular pressure measurement · score 0.48
monocyte count · score 0.48
celiac disease · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14921-F1	alphafold	PREDICTED	65.42	—

Amino-acid sequence (441 residues)

MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards