About Junction plakoglobin
Junction plakoglobin (JUP) is a protein
from Homo sapiens identified by UniProt accession
P14923, 745 residues long.
MolForge cross-references it against 0 known binders and
441 disease associations.
Target properties
| Protein name | Junction plakoglobin |
|---|
| UniProt accession | P14923 |
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| Gene | JUP |
|---|
| Organism | Homo sapiens |
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| Length | 745 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (441)
Diseases linked to this target (Open Targets).
- Naxos disease · score 0.79
- arrhythmogenic right ventricular dysplasia 12 · score 0.75
- Arrhythmogenic right ventricular dysplasia · score 0.69
- lethal acantholytic epidermolysis bullosa · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, biventricular form · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, left dominant form · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, right dominant form · score 0.37
- dilated cardiomyopathy · score 0.35
- cardiomyopathy · score 0.34
- arrhythmogenic right ventricular cardiomyopathy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14923-F1 | alphafold | PREDICTED | 81.10 | — |
Amino-acid sequence (745 residues)
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA
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