Cytochrome b-c1 complex subunit 7 (UQCRB)

About Cytochrome b-c1 complex subunit 7

Cytochrome b-c1 complex subunit 7 (UQCRB) is a protein from Homo sapiens identified by UniProt accession P14927, 111 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Cytochrome b-c1 complex subunit 7
UniProt accession	P14927
Gene	UQCRB
Organism	Homo sapiens
Length	111 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

Isolated CoQ-cytochrome C reductase deficiency · score 0.71
neurodegenerative disease · score 0.57
Parkinson disease · score 0.39
multiple sclerosis · score 0.39
Alzheimer disease · score 0.39
lysosomal storage disease · score 0.39
cholelithiasis · score 0.10
protein measurement · score 0.08
early-onset non-syndromic cataract · score 0.08
gallstones · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14927-F1	alphafold	PREDICTED	93.13	—

Amino-acid sequence (111 residues)

MAGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards