About Leukemia inhibitory factor
Leukemia inhibitory factor (LIF) is a protein
from Homo sapiens identified by UniProt accession
P15018, 202 residues long.
MolForge cross-references it against 0 known binders and
724 disease associations.
Target properties
| Protein name | Leukemia inhibitory factor |
|---|
| UniProt accession | P15018 |
|---|
| Gene | LIF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 202 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (724)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.53
- lung adenocarcinoma · score 0.22
- breast adenocarcinoma · score 0.20
- head and neck squamous cell carcinoma · score 0.18
- total cholesterol measurement · score 0.16
- body weights and measures · score 0.16
- urate measurement · score 0.15
- esophageal cancer · score 0.15
- body height · score 0.12
- neoplasm · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15018-F1 | alphafold | PREDICTED | 87.10 | — |
Amino-acid sequence (202 residues)
MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCAIRHPC HNNLMNQIRS QLAQLNGSAN ALFILYYTAQ GEPFPNNLDK LCGPNVTDFP PFHANGTEKA KLVELYRIVV YLGTSLGNIT RDQKILNPSA LSLHSKLNAT ADILRGLLSN VLCRLCSKYH VGHVDVTYGP DTSGKDVFQK KKLGCQLLGK YKQIIAVLAQ AF
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