Protein C-ets-2 (ETS2)

About Protein C-ets-2

Protein C-ets-2 (ETS2) is a protein from Homo sapiens identified by UniProt accession P15036, 469 residues long. MolForge cross-references it against 0 known binders and 274 disease associations.

Target properties

Protein name	Protein C-ets-2
UniProt accession	P15036
Gene	ETS2
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (274)

Diseases linked to this target (Open Targets).

body mass index · score 0.40
lean body mass · score 0.38
heel bone mineral density · score 0.37
bone density · score 0.35
bone quantitative ultrasound measurement · score 0.35
body weight · score 0.34
fat body mass · score 0.31
osteoporosis · score 0.30
bone fracture · score 0.29
central corneal thickness · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15036-F1	alphafold	PREDICTED	62.84	—

Amino-acid sequence (469 residues)

MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards