Carboxypeptidase A1 (CPA1)

About Carboxypeptidase A1

Carboxypeptidase A1 (CPA1) is a protein from Homo sapiens identified by UniProt accession P15085, 419 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.

Target properties

Protein name	Carboxypeptidase A1
UniProt accession	P15085
Gene	CPA1
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (239)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
hereditary chronic pancreatitis · score 0.40
BMI-adjusted waist circumference · score 0.38
BMI-adjusted waist-hip ratio · score 0.36
FEV/FVC ratio · score 0.34
waist-hip ratio · score 0.27
chronic pancreatitis · score 0.20
reticulocyte count · score 0.17
Immature Reticulocyte Fraction Measurement · score 0.17
Blackfan-Diamond anemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15085-F1	alphafold	PREDICTED	95.20	—

Amino-acid sequence (419 residues)

MRGLLVLSVL LGAVFGKEDF VGHQVLRISV ADEAQVQKVK ELEDLEHLQL DFWRGPAHPG SPIDVRVPFP SIQAVKIFLE SHGISYETMI EDVQSLLDEE QEQMFAFRSR ARSTDTFNYA TYHTLEEIYD FLDLLVAENP HLVSKIQIGN TYEGRPIYVL KFSTGGSKRP AIWIDTGIHS REWVTQASGV WFAKKITQDY GQDAAFTAIL DTLDIFLEIV TNPDGFAFTH STNRMWRKTR SHTAGSLCIG VDPNRNWDAG FGLSGASSNP CSETYHGKFA NSEVEVKSIV DFVKDHGNIK AFISIHSYSQ LLMYPYGYKT EPVPDQDELD QLSKAAVTAL ASLYGTKFNY GSIIKAIYQA SGSTIDWTYS QGIKYSFTFE LRDTGRYGFL LPASQIIPTA KETWLALLTI MEHTLNHPY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards