Mast cell carboxypeptidase A (CPA3)

About Mast cell carboxypeptidase A

Mast cell carboxypeptidase A (CPA3) is a protein from Homo sapiens identified by UniProt accession P15088, 417 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Mast cell carboxypeptidase A
UniProt accession	P15088
Gene	CPA3
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.47
birth weight · score 0.40
cortical thickness · score 0.35
cortical surface area measurement · score 0.34
eosinophil percentage of leukocytes · score 0.31
brain measurement · score 0.26
endometrial cancer · score 0.18
blood protein measurement · score 0.15
cutaneous melanoma · score 0.13
anxiety · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15088-F1	alphafold	PREDICTED	94.50	—

Amino-acid sequence (417 residues)

MRLILPVGLI ATTLAIAPVR FDREKVFRVK PQDEKQADII KDLAKTNELD FWYPGATHHV AANMMVDFRV SEKESQAIQS ALDQNKMHYE ILIHDLQEEI EKQFDVKEDI PGRHSYAKYN NWEKIVAWTE KMMDKYPEMV SRIKIGSTVE DNPLYVLKIG EKNERRKAIF TDCGIHAREW VSPAFCQWFV YQATKTYGRN KIMTKLLDRM NFYILPVFNV DGYIWSWTKN RMWRKNRSKN QNSKCIGTDL NRNFNASWNS IPNTNDPCAD NYRGSAPESE KETKAVTNFI RSHLNEIKVY ITFHSYSQML LFPYGYTSKL PPNHEDLAKV AKIGTDVLST RYETRYIYGP IESTIYPISG SSLDWAYDLG IKHTFAFELR DKGKFGFLLP ESRIKPTCRE TMLAVKFIAK YILKHTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards