Poliovirus receptor (PVR)

About Poliovirus receptor

Poliovirus receptor (PVR) is a protein from Homo sapiens identified by UniProt accession P15151, 417 residues long. MolForge cross-references it against 0 known binders and 390 disease associations.

Target properties

Protein name	Poliovirus receptor
UniProt accession	P15151
Gene	PVR
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (390)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.43
apolipoprotein B measurement · score 0.33
platelet count · score 0.32
monocyte count · score 0.29
lymphocyte count · score 0.29
platelet component distribution width · score 0.28
neurodegenerative disease · score 0.27
leukocyte count · score 0.22
blood protein measurement · score 0.21
multiple sclerosis · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15151-F1	alphafold	PREDICTED	84.87	—

Amino-acid sequence (417 residues)

MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA VSRENSSSQD PQTEGTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards