Carboxypeptidase N catalytic chain (CPN1)

About Carboxypeptidase N catalytic chain

Carboxypeptidase N catalytic chain (CPN1) is a protein from Homo sapiens identified by UniProt accession P15169, 458 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

Target properties

Protein name	Carboxypeptidase N catalytic chain
UniProt accession	P15169
Gene	CPN1
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.51
body height · score 0.44
heel bone mineral density · score 0.42
serum alanine aminotransferase measurement · score 0.42
protein measurement · score 0.41
interleukin-27 measurement · score 0.40
creatine kinase measurement · score 0.36
bone quantitative ultrasound measurement · score 0.34
neurodegenerative disease · score 0.33
blood phosphate measurement · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15169-F1	alphafold	PREDICTED	90.75	—

Amino-acid sequence (458 residues)

MSDLLSVFLH LLLLFKLVAP VTFRHHRYDD LVRTLYKVQN ECPGITRVYS IGRSVEGRHL YVLEFSDHPG IHEPLEPEVK YVGNMHGNEA LGRELMLQLS EFLCEEFRNR NQRIVQLIQD TRIHILPSMN PDGYEVAAAQ GPNKPGYLVG RNNANGVDLN RNFPDLNTYI YYNEKYGGPN HHLPLPDNWK SQVEPETRAV IRWMHSFNFV LSANLHGGAV VANYPYDKSF EHRVRGVRRT ASTPTPDDKL FQKLAKVYSY AHGWMFQGWN CGDYFPDGIT NGASWYSLSK GMQDFNYLHT NCFEITLELS CDKFPPEEEL QREWLGNREA LIQFLEQVHQ GIKGMVLDEN YNNLANAVIS VSGINHDVTS GDHGDYFRLL LPGIYTVSAT APGYDPETVT VTVGPAEPTL VNFHLKRSIP QVSPVRRAPS RRHGVRAKVQ PQARKKEMEM RQLQRGPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards