About Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) is a protein
from Homo sapiens identified by UniProt accession
P15170, 499 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A |
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| UniProt accession | P15170 |
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| Gene | GSPT1 |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- age at menopause · score 0.33
- endometrial cancer · score 0.25
- lysosomal storage disease · score 0.23
- menopause · score 0.22
- erythrocyte count · score 0.21
- reticulocyte measurement · score 0.19
- reticulocyte count · score 0.18
- systolic blood pressure · score 0.18
- diastolic blood pressure · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15170-F1 | alphafold | PREDICTED | 81.84 | — |
Amino-acid sequence (499 residues)
MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR DEGKTIAIGK VLKLVPEKD
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