Myoblast determination protein 1 (MYOD1)

About Myoblast determination protein 1

Myoblast determination protein 1 (MYOD1) is a protein from Homo sapiens identified by UniProt accession P15172, 320 residues long. MolForge cross-references it against 0 known binders and 305 disease associations.

Target properties

Protein name	Myoblast determination protein 1
UniProt accession	P15172
Gene	MYOD1
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (305)

Diseases linked to this target (Open Targets).

myopathy, congenital, with diaphragmatic defects, respiratory insufficiency, and dysmorphic facies · score 0.61
neurodegenerative disease · score 0.46
rhabdomyosarcoma · score 0.44
embryonal rhabdomyosarcoma · score 0.37
gastric carcinoma · score 0.37
cecum adenocarcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
fetal akinesia deformation sequence · score 0.37
gastric adenocarcinoma · score 0.37
autosomal dominant centronuclear myopathy · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15172-F1	alphafold	PREDICTED	61.17	—

Amino-acid sequence (320 residues)

MELLSPPLRD VDLTAPDGSL CSFATTDDFY DDPCFDSPDL RFFEDLDPRL MHVGALLKPE EHSHFPAAVH PAPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAAFYA PGPLPPGRGG EHYSGDSDAS SPRSNCSDGM MDYSGPPSGA RRRNCYEGAY YNEAPSEPRP GKSAAVSSLD CLSSIVERIS TESPAAPALL LADVPSESPP RRQEAAAPSE GESSGDPTQS PDAAPQCPAG ANPNPIYQVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards