About Phosphoglycerate mutase 2
Phosphoglycerate mutase 2 (PGAM2) is a protein
from Homo sapiens identified by UniProt accession
P15259, 253 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Phosphoglycerate mutase 2 |
|---|
| UniProt accession | P15259 |
|---|
| Gene | PGAM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 253 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- glycogen storage disease due to phosphoglycerate mutase deficiency · score 0.78
- neurodegenerative disease · score 0.43
- neuroinflammatory disorder · score 0.35
- rhabdomyolysis · score 0.26
- lysosomal storage disease · score 0.26
- Alzheimer disease · score 0.26
- Parkinson disease · score 0.26
- multiple sclerosis · score 0.26
- genetic disorder · score 0.19
- sitting height measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15259-F1 | alphafold | PREDICTED | 93.90 | — |
Amino-acid sequence (253 residues)
MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKM EFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFD IPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSL RGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK
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