Arylsulfatase A (ARSA)

About Arylsulfatase A

Arylsulfatase A (ARSA) is a protein from Homo sapiens identified by UniProt accession P15289, 507 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	Arylsulfatase A
UniProt accession	P15289
Gene	ARSA
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

metachromatic leukodystrophy, juvenile form · score 0.82
metachromatic leukodystrophy · score 0.82
metachromatic leukodystrophy, adult form · score 0.60
metachromatic leukodystrophy, late infantile form · score 0.59
genetic disorder · score 0.52
Neurodevelopmental disorder · score 0.41
Multiple sulfatase deficiency · score 0.37
mucosulfatidosis · score 0.37
Dystonia · score 0.37
leukodystrophy · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15289-F1	alphafold	PREDICTED	96.11	—

Amino-acid sequence (507 residues)

MGAPRSLLLA LAAGLAVARP PNIVLIFADD LGYGDLGCYG HPSSTTPNLD QLAAGGLRFT DFYVPVSLCT PSRAALLTGR LPVRMGMYPG VLVPSSRGGL PLEEVTVAEV LAARGYLTGM AGKWHLGVGP EGAFLPPHQG FHRFLGIPYS HDQGPCQNLT CFPPATPCDG GCDQGLVPIP LLANLSVEAQ PPWLPGLEAR YMAFAHDLMA DAQRQDRPFF LYYASHHTHY PQFSGQSFAE RSGRGPFGDS LMELDAAVGT LMTAIGDLGL LEETLVIFTA DNGPETMRMS RGGCSGLLRC GKGTTYEGGV REPALAFWPG HIAPGVTHEL ASSLDLLPTL AALAGAPLPN VTLDGFDLSP LLLGTGKSPR QSLFFYPSYP DEVRGVFAVR TGKYKAHFFT QGSAHSDTTA DPACHASSSL TAHEPPLLYD LSKDPGENYN LLGGVAGATP EVLQALKQLQ LLKAQLDAAV TFGPSQVARG EDPALQICCH PGCTPRPACC HCPDPHA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards