Beta-1,4-galactosyltransferase 1 (B4GALT1)

About Beta-1,4-galactosyltransferase 1

Beta-1,4-galactosyltransferase 1 (B4GALT1) is a protein from Homo sapiens identified by UniProt accession P15291, 398 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.

Target properties

Protein name	Beta-1,4-galactosyltransferase 1
UniProt accession	P15291
Gene	B4GALT1
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (233)

Diseases linked to this target (Open Targets).

B4GALT1-congenital disorder of glycosylation · score 0.75
neurodegenerative disease · score 0.55
congenital disorder of glycosylation type II · score 0.53
serum IgG glycosylation measurement · score 0.51
urate measurement · score 0.49
aspartate aminotransferase measurement · score 0.49
congenital disorder of glycosylation · score 0.46
combined low LDL and fibrinogen · score 0.45
hemoglobin measurement · score 0.43
erythrocyte count · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15291-F1	alphafold	PREDICTED	83.73	—

Amino-acid sequence (398 residues)

MRLREPLLSG SAAMPGASLQ RACRLLVAVC ALHLGVTLVY YLAGRDLSRL PQLVGVSTPL QGGSNSAAAI GQSSGELRTG GARPPPPLGA SSQPRPGGDS SPVVDSGPGP ASNLTSVPVP HTTALSLPAC PEESPLLVGP MLIEFNMPVD LELVAKQNPN VKMGGRYAPR DCVSPHKVAI IIPFRNRQEH LKYWLYYLHP VLQRQQLDYG IYVINQAGDT IFNRAKLLNV GFQEALKDYD YTCFVFSDVD LIPMNDHNAY RCFSQPRHIS VAMDKFGFSL PYVQYFGGVS ALSKQQFLTI NGFPNNYWGW GGEDDDIFNR LVFRGMSISR PNAVVGRCRM IRHSRDKKNE PNPQRFDRIA HTKETMLSDG LNSLTYQVLD VQRYPLYTQI TVDIGTPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards