About Ezrin
Ezrin (EZR) is a protein
from Homo sapiens identified by UniProt accession
P15311, 586 residues long.
MolForge cross-references it against 0 known binders and
478 disease associations.
Target properties
| Protein name | Ezrin |
|---|
| UniProt accession | P15311 |
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| Gene | EZR |
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| Organism | Homo sapiens |
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| Length | 586 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (478)
Diseases linked to this target (Open Targets).
- hair color · score 0.49
- FEV/FVC ratio · score 0.40
- non-small cell lung carcinoma · score 0.40
- hair colour measurement · score 0.39
- serum alanine aminotransferase measurement · score 0.38
- lung adenocarcinoma · score 0.37
- autosomal recessive non-syndromic intellectual disability · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.33
- neurodegenerative disease · score 0.32
- Abnormality of refraction · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15311-F1 | alphafold | PREDICTED | 87.83 | — |
Amino-acid sequence (586 residues)
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL
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