About V-type proton ATPase subunit B, kidney isoform
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) is a protein
from Homo sapiens identified by UniProt accession
P15313, 513 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | V-type proton ATPase subunit B, kidney isoform |
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| UniProt accession | P15313 |
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| Gene | ATP6V1B1 |
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| Organism | Homo sapiens |
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| Length | 513 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (192)
Diseases linked to this target (Open Targets).
- renal tubular acidosis, distal, 2, with progressive sensorineural hearing loss · score 0.79
- autosomal recessive distal renal tubular acidosis · score 0.66
- distal renal tubular acidosis · score 0.62
- genetic disorder · score 0.49
- nephrocalcinosis · score 0.41
- urate measurement · score 0.37
- hearing loss · score 0.37
- polydactyly, postaxial, type A1 · score 0.34
- Rare genetic deafness · score 0.34
- creatinine measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15313-F1 | alphafold | PREDICTED | 86.81 | — |
Amino-acid sequence (513 residues)
MAMEIDSRPG GLPGSSCNLG AAREHMQAVT RNYITHPRVT YRTVCSVNGP LVVLDRVKFA QYAEIVHFTL PDGTQRSGQV LEVAGTKAIV QVFEGTSGID ARKTTCEFTG DILRTPVSED MLGRVFNGSG KPIDKGPVVM AEDFLDINGQ PINPHSRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI CRQAGLVKKS KAVLDYHDDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QIYPPINVLP SLSRLMKSAI GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ KFEKNFINQG PYENRSVFES LDLGWKLLRI FPKEMLKRIP QAVIDEFYSR EGALQDLAPD TAL
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