About Folate receptor alpha
Folate receptor alpha (FOLR1) is a protein
from Homo sapiens identified by UniProt accession
P15328, 257 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Folate receptor alpha |
|---|
| UniProt accession | P15328 |
|---|
| Gene | FOLR1 |
|---|
| Organism | Homo sapiens |
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| Length | 257 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (150)
Diseases linked to this target (Open Targets).
- neurodegenerative syndrome due to cerebral folate transport deficiency · score 0.81
- Seizure · score 0.41
- peritoneal neoplasm · score 0.39
- fallopian tube neoplasm · score 0.37
- malignant epithelial tumor of ovary · score 0.37
- genetic disorder · score 0.34
- neoplasm · score 0.31
- ovarian cancer · score 0.31
- Epileptic encephalopathy · score 0.26
- lung adenocarcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15328-F1 | alphafold | PREDICTED | 91.21 | — |
Amino-acid sequence (257 residues)
MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNKCA VGAACQPFHF YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA AWPFLLSLAL MLLWLLS
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