About Cyclic AMP-dependent transcription factor ATF-2
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) is a protein
from Homo sapiens identified by UniProt accession
P15336, 505 residues long.
MolForge cross-references it against 0 known binders and
136 disease associations.
Target properties
| Protein name | Cyclic AMP-dependent transcription factor ATF-2 |
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| UniProt accession | P15336 |
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| Gene | ATF2 |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (136)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- breast adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.21
- endometrial cancer · score 0.18
- squamous cell lung carcinoma · score 0.18
- vital capacity · score 0.17
- gastric adenocarcinoma · score 0.17
- self reported educational attainment · score 0.14
- muscular dystrophy · score 0.13
- systolic blood pressure · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15336-F1 | alphafold | PREDICTED | 57.78 | — |
Amino-acid sequence (505 residues)
MKFKLHVNSA RQYKDLWNMS DDKPFLCTAP GCGQRFTNED HLAVHKHKHE MTLKFGPARN DSVIVADQTP TPTRFLKNCE EVGLFNELAS PFENEFKKAS EDDIKKMPLD LSPLATPIIR SKIEEPSVVE TTHQDSPLPH PESTTSDEKE VPLAQTAQPT SAIVRPASLQ VPNVLLTSSD SSVIIQQAVP SPTSSTVITQ APSSNRPIVP VPGPFPLLLH LPNGQTMPVA IPASITSSNV HVPAAVPLVR PVTMVPSVPG IPGPSSPQPV QSEAKMRLKA ALTQQHPPVT NGDTVKGHGS GLVRTQSEES RPQSLQQPAT STTETPASPA HTTPQTQSTS GRRRRAANED PDEKRRKFLE RNRAAASRCR QKRKVWVQSL EKKAEDLSSL NGQLQSEVTL LRNEVAQLKQ LLLAHKDCPV TAMQKKSGYH TADKDDSSED ISVPSSPHTE AIQHSSVSTS NGVSSTSKAE AVATSVLTQM ADQSTEPALS QIVMAPSSQS QPSGS
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