About Fos-related antigen 1
Fos-related antigen 1 (FOSL1) is a protein
from Homo sapiens identified by UniProt accession
P15407, 271 residues long.
MolForge cross-references it against 0 known binders and
280 disease associations.
Target properties
| Protein name | Fos-related antigen 1 |
|---|
| UniProt accession | P15407 |
|---|
| Gene | FOSL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 271 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (280)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- Parkinson disease · score 0.37
- multiple sclerosis · score 0.37
- lysosomal storage disease · score 0.37
- Alzheimer disease · score 0.37
- eosinophil count · score 0.31
- eosinophil percentage of leukocytes · score 0.25
- eosinophil percentage of granulocytes · score 0.17
- sum of eosinophil and basophil counts · score 0.16
- ovarian carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15407-F1 | alphafold | PREDICTED | 65.84 | — |
Amino-acid sequence (271 residues)
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L
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