Fos-related antigen 2 (FOSL2)

About Fos-related antigen 2

Fos-related antigen 2 (FOSL2) is a protein from Homo sapiens identified by UniProt accession P15408, 326 residues long. MolForge cross-references it against 0 known binders and 284 disease associations.

Target properties

Protein name	Fos-related antigen 2
UniProt accession	P15408
Gene	FOSL2
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (284)

Diseases linked to this target (Open Targets).

type 1 diabetes mellitus · score 0.42
neurodegenerative disease · score 0.41
body height · score 0.40
inflammatory bowel disease · score 0.39
systolic blood pressure · score 0.39
Crohn's disease · score 0.38
hair color · score 0.38
aspartate aminotransferase measurement · score 0.34
cardiovascular disease · score 0.32
serum gamma-glutamyl transferase measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15408-F1	alphafold	PREDICTED	61.67	—

Amino-acid sequence (326 residues)

MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC SKAHRRSSSS GDQSSDSLNS PTLLAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards