About Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA) is a protein
from Homo sapiens identified by UniProt accession
P15509, 400 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
|---|
| UniProt accession | P15509 |
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| Gene | CSF2RA |
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| Organism | Homo sapiens |
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| Length | 400 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (294)
Diseases linked to this target (Open Targets).
- Congenital pulmonary alveolar proteinosis · score 0.74
- Intraalveolar phospholipid accumulation · score 0.58
- pulmonary alveolar proteinosis · score 0.53
- melanoma · score 0.48
- acute myeloid leukemia · score 0.47
- hypersensitivity · score 0.46
- Sepsis · score 0.45
- neoplasm · score 0.43
- COVID-19 · score 0.41
- leukemia · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15509-F1 | alphafold | PREDICTED | 81.98 | — |
Amino-acid sequence (400 residues)
MLLLVTSLLL CELPHPAFLL IPEKSDLRTV APASSLNVRF DSRTMNLSWD CQENTTFSKC FLTDKKNRVV EPRLSNNECS CTFREICLHE GVTFEVHVNT SQRGFQQKLL YPNSGREGTA AQNFSCFIYN ADLMNCTWAR GPTAPRDVQY FLYIRNSKRR REIRCPYYIQ DSGTHVGCHL DNLSGLTSRN YFLVNGTSRE IGIQFFDSLL DTKKIERFNP PSNVTVRCNT THCLVRWKQP RTYQKLSYLD FQYQLDVHRK NTQPGTENLL INVSGDLENR YNFPSSEPRA KHSVKIRAAD VRILNWSSWS EAIEFGSDDG NLGSVYIYVL LIVGTLVCGI VLGFLFKRFL RIQRLFPPVP QIKDKLNDNH EVEDEIIWEE FTPEEGKGYR EEVLTVKEIT
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