About Amphiregulin
Amphiregulin (AREG) is a protein
from Homo sapiens identified by UniProt accession
P15514, 252 residues long.
MolForge cross-references it against 0 known binders and
398 disease associations.
Target properties
| Protein name | Amphiregulin |
|---|
| UniProt accession | P15514 |
|---|
| Gene | AREG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 252 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (398)
Diseases linked to this target (Open Targets).
- cancer · score 0.48
- neurodegenerative disease · score 0.39
- hair color · score 0.37
- breast size · score 0.29
- mammographic density measurement · score 0.29
- dense area measurement · score 0.29
- hair colour measurement · score 0.27
- alopecia · score 0.25
- Breast hypertrophy · score 0.23
- breast disease · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15514-F1 | alphafold | PREDICTED | 67.65 | — |
Amino-acid sequence (252 residues)
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK LRQENGNVHA IA
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