Histatin-3 (HTN3)

About Histatin-3

Histatin-3 (HTN3) is a protein from Homo sapiens identified by UniProt accession P15516, 51 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Histatin-3
UniProt accession	P15516
Gene	HTN3
Organism	Homo sapiens
Length	51 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.18
squamous cell lung carcinoma · score 0.14
vulvovaginal candidiasis · score 0.03
dental caries · score 0.03
Dravet syndrome · score 0.02
pulse pressure measurement · score 0.02
Down syndrome · score 0.01
acinar cell carcinoma · score 0.01
periodontitis · score 0.01
mucous membrane pemphigoid · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15516-F1	alphafold	PREDICTED	66.15	—

Amino-acid sequence (51 residues)

MKFFVFALIL ALMLSMTGAD SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards