Nucleoside diphosphate kinase A (NME1)

About Nucleoside diphosphate kinase A

Nucleoside diphosphate kinase A (NME1) is a protein from Homo sapiens identified by UniProt accession P15531, 152 residues long. MolForge cross-references it against 0 known binders and 326 disease associations.

Target properties

Protein name	Nucleoside diphosphate kinase A
UniProt accession	P15531
Gene	NME1
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (326)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
neoplasm · score 0.11
melanoma · score 0.10
hepatocellular carcinoma · score 0.09
non-small cell lung carcinoma · score 0.09
neuroblastoma · score 0.09
colorectal carcinoma · score 0.09
esophageal squamous cell carcinoma · score 0.09
laryngeal squamous cell carcinoma · score 0.08
head and neck squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15531-F1	alphafold	PREDICTED	97.42	—

Amino-acid sequence (152 residues)

MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards