About Cytochrome P450 11B1, mitochondrial
Cytochrome P450 11B1, mitochondrial (CYP11B1) is a protein
from Homo sapiens identified by UniProt accession
P15538, 503 residues long.
MolForge cross-references it against 0 known binders and
261 disease associations.
Target properties
| Protein name | Cytochrome P450 11B1, mitochondrial |
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| UniProt accession | P15538 |
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| Gene | CYP11B1 |
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| Organism | Homo sapiens |
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| Length | 503 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (261)
Diseases linked to this target (Open Targets).
- congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency · score 0.84
- glucocorticoid-remediable aldosteronism · score 0.67
- adrenal gland disease · score 0.55
- pituitary-dependent Cushing's disease · score 0.55
- congenital adrenal hyperplasia · score 0.55
- Cushing syndrome · score 0.54
- neoplasm · score 0.39
- adrenal cortex carcinoma · score 0.39
- adrenal cortex neoplasm · score 0.37
- adrenal gland hyperfunction · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15538-F1 | alphafold | PREDICTED | 90.78 | — |
Amino-acid sequence (503 residues)
MALRAKAEVC MAVPWLSLQR AQALGTRAAR VPRTVLPFEA MPRRPGNRWL RLLQIWREQG YEDLHLEVHQ TFQELGPIFR YDLGGAGMVC VMLPEDVEKL QQVDSLHPHR MSLEPWVAYR QHRGHKCGVF LLNGPEWRFN RLRLNPEVLS PNAVQRFLPM VDAVARDFSQ ALKKKVLQNA RGSLTLDVQP SIFHYTIEAS NLALFGERLG LVGHSPSSAS LNFLHALEVM FKSTVQLMFM PRSLSRWTSP KVWKEHFEAW DCIFQYGDNC IQKIYQELAF SRPQQYTSIV AELLLNAELS PDAIKANSME LTAGSVDTTV FPLLMTLFEL ARNPNVQQAL RQESLAAAAS ISEHPQKATT ELPLLRAALK ETLRLYPVGL FLERVASSDL VLQNYHIPAG TLVRVFLYSL GRNPALFPRP ERYNPQRWLD IRGSGRNFYH VPFGFGMRQC LGRRLAEAEM LLLLHHVLKH LQVETLTQED IKMVYSFILR PSMFPLLTFR AIN
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