NAD(P)H dehydrogenase [quinone] 1 (NQO1)

About NAD(P)H dehydrogenase [quinone] 1

NAD(P)H dehydrogenase [quinone] 1 (NQO1) is a protein from Homo sapiens identified by UniProt accession P15559, 274 residues long. MolForge cross-references it against 0 known binders and 600 disease associations.

Target properties

Protein name	NAD(P)H dehydrogenase [quinone] 1
UniProt accession	P15559
Gene	NQO1
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (600)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Friedreich ataxia · score 0.30
mitochondrial disease · score 0.28
glomerular filtration rate · score 0.21
smoking initiation · score 0.21
lymphocyte count · score 0.18
alcohol consumption measurement · score 0.17
blood urea nitrogen measurement · score 0.16
type 2 diabetes mellitus · score 0.16
genetic disorder · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15559-F1	alphafold	PREDICTED	98.35	—

Amino-acid sequence (274 residues)

MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards