N-acetylglucosamine-6-sulfatase (GNS)

About N-acetylglucosamine-6-sulfatase

N-acetylglucosamine-6-sulfatase (GNS) is a protein from Homo sapiens identified by UniProt accession P15586, 552 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	N-acetylglucosamine-6-sulfatase
UniProt accession	P15586
Gene	GNS
Organism	Homo sapiens
Length	552 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

mucopolysaccharidosis type 3D · score 0.77
mucopolysaccharidosis type 3 · score 0.74
body height · score 0.30
hair colour measurement · score 0.22
genetic disorder · score 0.19
mean platelet volume · score 0.16
platelet count · score 0.16
FEV/FVC ratio · score 0.12
aggressive behavior · score 0.12
autism · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15586-F1	alphafold	PREDICTED	89.05	—

Amino-acid sequence (552 residues)

MRLLPLAPGR LRRGSPRHLP SCSPALLLLV LGGCLGVFGV AAGTRRPNVV LLLTDDQDEV LGGMTPLKKT KALIGEMGMT FSSAYVPSAL CCPSRASILT GKYPHNHHVV NNTLEGNCSS KSWQKIQEPN TFPAILRSMC GYQTFFAGKY LNEYGAPDAG GLEHVPLGWS YWYALEKNSK YYNYTLSING KARKHGENYS VDYLTDVLAN VSLDFLDYKS NFEPFFMMIA TPAPHSPWTA APQYQKAFQN VFAPRNKNFN IHGTNKHWLI RQAKTPMTNS SIQFLDNAFR KRWQTLLSVD DLVEKLVKRL EFTGELNNTY IFYTSDNGYH TGQFSLPIDK RQLYEFDIKV PLLVRGPGIK PNQTSKMLVA NIDLGPTILD IAGYDLNKTQ MDGMSLLPIL RGASNLTWRS DVLVEYQGEG RNVTDPTCPS LSPGVSQCFP DCVCEDAYNN TYACVRTMSA LWNLQYCEFD DQEVFVEVYN LTADPDQITN IAKTIDPELL GKMNYRLMML QSCSGPTCRT PGVFDPGYRF DPRLMFSNRG SVRTRRFSKH LL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards