About Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHKG2) is a protein
from Homo sapiens identified by UniProt accession
P15735, 406 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
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| UniProt accession | P15735 |
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| Gene | PHKG2 |
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| Organism | Homo sapiens |
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| Length | 406 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (111)
Diseases linked to this target (Open Targets).
- glycogen storage disease due to liver phosphorylase kinase deficiency · score 0.74
- disorder of glycogen metabolism · score 0.50
- genetic disorder · score 0.41
- Parkinson disease · score 0.36
- Alzheimer disease · score 0.36
- neurodegenerative disease · score 0.36
- lysosomal storage disease · score 0.36
- multiple sclerosis · score 0.36
- Mauriac syndrome · score 0.34
- Glycogen storage disease due to phosphorylase kinase deficiency · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15735-F1 | alphafold | PREDICTED | 83.26 | — |
Amino-acid sequence (406 residues)
MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGHEF AVKIMEVTAE RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT EKVALSEKET RSIMRSLLEA VSFLHANNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL MLRMIMEGQY QFSSPEWDDR SSTVKDLISR LLQVDPEARL TAEQALQHPF FERCEGSQPW NLTPRQRFRV AVWTVLAAGR VALSTHRVRP LTKNALLRDP YALRSVRHLI DNCAFRLYGH WVKKGEQQNR AALFQHRPPG PFPIMGPEEE GDSAAITEDE AVLVLG
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