Arylsulfatase B (ARSB)

About Arylsulfatase B

Arylsulfatase B (ARSB) is a protein from Homo sapiens identified by UniProt accession P15848, 533 residues long. MolForge cross-references it against 0 known binders and 272 disease associations.

Target properties

Protein name	Arylsulfatase B
UniProt accession	P15848
Gene	ARSB
Organism	Homo sapiens
Length	533 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (272)

Diseases linked to this target (Open Targets).

mucopolysaccharidosis type 6 · score 0.88
mucopolysaccharidosis · score 0.58
metachromatic leukodystrophy · score 0.48
genetic disorder · score 0.45
heel bone mineral density · score 0.41
arylsulfatase B measurement · score 0.39
monocyte count · score 0.38
Multiple sulfatase deficiency · score 0.37
mucosulfatidosis · score 0.37
mucopolysaccharidosis type 6, slowly progressing · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15848-F1	alphafold	PREDICTED	93.10	—

Amino-acid sequence (533 residues)

MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLAPPGSGAG ASRPPHLVFL LADDLGWNDV GFHGSRIRTP HLDALAAGGV LLDNYYTQPL CTPSRSQLLT GRYQIRTGLQ HQIIWPCQPS CVPLDEKLLP QLLKEAGYTT HMVGKWHLGM YRKECLPTRR GFDTYFGYLL GSEDYYSHER CTLIDALNVT RCALDFRDGE EVATGYKNMY STNIFTKRAI ALITNHPPEK PLFLYLALQS VHEPLQVPEE YLKPYDFIQD KNRHHYAGMV SLMDEAVGNV TAALKSSGLW NNTVFIFSTD NGGQTLAGGN NWPLRGRKWS LWEGGVRGVG FVASPLLKQK GVKNRELIHI SDWLPTLVKL ARGHTNGTKP LDGFDVWKTI SEGSPSPRIE LLHNIDPNFV DSSPCPRNSM APAKDDSSLP EYSAFNTSVH AAIRHGNWKL LTGYPGCGYW FPPPSQYNVS EIPSSDPPTK TLWLFDIDRD PEERHDLSRE YPHIVTKLLS RLQFYHKHSV PVYFPAQDPR CDPKATGVWG PWM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards