Paired box protein Pax-1 (PAX1)

About Paired box protein Pax-1

Paired box protein Pax-1 (PAX1) is a protein from Homo sapiens identified by UniProt accession P15863, 534 residues long. MolForge cross-references it against 0 known binders and 490 disease associations.

Target properties

Protein name	Paired box protein Pax-1
UniProt accession	P15863
Gene	PAX1
Organism	Homo sapiens
Length	534 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (490)

Diseases linked to this target (Open Targets).

otofaciocervical syndrome · score 0.74
nose morphology measurement · score 0.38
body height · score 0.33
androgenetic alopecia · score 0.32
adolescent idiopathic scoliosis · score 0.30
high density lipoprotein cholesterol measurement · score 0.27
upper face morphology measurement · score 0.26
craniofacial microsomia · score 0.26
hair shape measurement · score 0.26
synophrys measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15863-F1	alphafold	PREDICTED	54.60	—

Amino-acid sequence (534 residues)

MKFTLGLGSR AWRVSWEGAA AAAAGPGAGG SALRCRAQRV SSPRLGRRGS RLSGALPLCL SRGGGGAQAL PDCAGPSPGH PGHPGARQLA GPLAMEQTYG EVNQLGGVFV NGRPLPNAIR LRIVELAQLG IRPCDISRQL RVSHGCVSKI LARYNETGSI LPGAIGGSKP RVTTPNVVKH IRDYKQGDPG IFAWEIRDRL LADGVCDKYN VPSVSSISRI LRNKIGSLAQ PGPYEASKQP PSQPTLPYNH IYQYPYPSPV SPTGAKMGSH PGVPGTAGHV SIPRSWPSAH SVSNILGIRT FMEQTGALAG SEGTAYSPKM EDWAGVNRTA FPATPAVNGL EKPALEADIK YTQSASTLSA VGGFLPACAY PASNQHGVYS APGGGYLAPG PPWPPAQGPP LAPPGAGVAV HGGELAAAMT FKHPSREGSL PAPAARPRTP SVAYTDCPSR PRPPRGSSPR TRARRERQAD PGAQVCAAAP AIGTGRIGGL AEEEASAGPR GARPASPQAQ PCLWPDPPHF LYWSGFLGFS ELGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards