Small ribosomal subunit protein uS5 (RPS2)

About Small ribosomal subunit protein uS5

Small ribosomal subunit protein uS5 (RPS2) is a protein from Homo sapiens identified by UniProt accession P15880, 293 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Small ribosomal subunit protein uS5
UniProt accession	P15880
Gene	RPS2
Organism	Homo sapiens
Length	293 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
severe acute respiratory syndrome · score 0.37
COVID-19 · score 0.37
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.28
qualitative or quantitative defects of dystrophin · score 0.26
neurodegenerative disease · score 0.25
atrial fibrillation · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15880-F1	alphafold	PREDICTED	80.94	—

Amino-acid sequence (293 residues)

MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards