N-chimaerin (CHN1)

About N-chimaerin

N-chimaerin (CHN1) is a protein from Homo sapiens identified by UniProt accession P15882, 459 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.

Target properties

Protein name	N-chimaerin
UniProt accession	P15882
Gene	CHN1
Organism	Homo sapiens
Length	459 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (165)

Diseases linked to this target (Open Targets).

Duane retraction syndrome · score 0.68
autosomal dominant Robinow syndrome · score 0.33
Robinow syndrome · score 0.33
Duane anomaly · score 0.32
Moebius syndrome · score 0.27
diaphragmatic eventration · score 0.27
sensorineural hearing loss · score 0.27
Micrognathia · score 0.27
Hydroureter · score 0.27
Cleft palate · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15882-F1	alphafold	PREDICTED	86.32	—

Amino-acid sequence (459 residues)

MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS EKRLTSLVRR ATLKENEQIP KYEKIHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHTTK RPMVVDMCIR EIESRGLNSE GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY PKFIESAKIM DPDEQLETLH EALKLLPPAH CETLRYLMAH LKRVTLHEKE NLMNAENLGI VFGPTLMRSP ELDAMAALND IRYQRLVVEL LIKNEDILF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards