About Transcription factor E2-alpha
Transcription factor E2-alpha (TCF3) is a protein
from Homo sapiens identified by UniProt accession
P15923, 654 residues long.
MolForge cross-references it against 0 known binders and
304 disease associations.
Target properties
| Protein name | Transcription factor E2-alpha |
|---|
| UniProt accession | P15923 |
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| Gene | TCF3 |
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| Organism | Homo sapiens |
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| Length | 654 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (304)
Diseases linked to this target (Open Targets).
- agammaglobulinemia 8b, autosomal recessive · score 0.60
- isolated agammaglobulinemia · score 0.54
- neurodegenerative disease · score 0.50
- autosomal agammaglobulinemia · score 0.46
- genetic disorder · score 0.41
- acute lymphoblastic leukemia · score 0.39
- myeloproliferative neoplasm, unclassifiable · score 0.38
- T-cell acute lymphoblastic leukemia · score 0.37
- B-cell acute lymphoblastic leukemia · score 0.37
- hemangioblastoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15923-F1 | alphafold | PREDICTED | 51.08 | — |
Amino-acid sequence (654 residues)
MNQPQRMAPV GTDKELSDLL DFSMMFPLPV TNGKGRPASL AGAQFGGSGL EDRPSSGSWG SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG KSGERGAYAS FGRDAGVGGL TQAGFLSGEL ALNSPGPLSP SGMKGTSQYY PSYSGSSRRR AADGSLDTQP KKVRKVPPGL PSSVYPPSSG EDYGRDATAY PSAKTPSSTY PAPFYVADGS LHPSAELWSP PGQAGFGPML GGGSSPLPLP PGSGPVGSSG SSSTFGGLHQ HERMGYQLHG AEVNGGLPSA SSFSSAPGAT YGGVSSHTPP VSGADSLLGS RGTTAGSSGD ALGKALASIY SPDHSSNNFS SSPSTPVGSP QGLAGTSQWP RAGAPGALSP SYDGGLHGLQ SKIEDHLDEA IHVLRSHAVG TAGDMHTLLP GHGALASGFT GPMSLGGRHA GLVGGSHPED GLAGSTSLMH NHAALPSQPG TLPDLSRPPD SYSGLGRAGA TAAASEIKRE EKEDEENTSA ADHSEEEKKE LKAPRARTSP DEDEDDLLPP EQKAEREKER RVANNARERL RVRDINEAFK ELGRMCQLHL NSEKPQTKLL ILHQAVSVIL NLEQQVRERN LNPKAACLKR REEEKVSGVV GDPQMVLSAP HPGLSEAHNP AGHM
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