About Replication protein A 32 kDa subunit
Replication protein A 32 kDa subunit (RPA2) is a protein
from Homo sapiens identified by UniProt accession
P15927, 270 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Replication protein A 32 kDa subunit |
|---|
| UniProt accession | P15927 |
|---|
| Gene | RPA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.28
- lung adenocarcinoma · score 0.28
- glioblastoma multiforme · score 0.27
- lymphocyte count · score 0.26
- leukocyte count · score 0.25
- Red cell distribution width · score 0.23
- platelet count · score 0.21
- esophageal cancer · score 0.21
- eosinophil count · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15927-F1 | alphafold | PREDICTED | 79.29 | — |
Amino-acid sequence (270 residues)
MWNSGFESYG SSSYGGAGGY TQSPGGFGSP APSQAEKKSR ARAQHIVPCT ISQLLSATLV DEVFRIGNVE ISQVTIVGII RHAEKAPTNI VYKIDDMTAA PMDVRQWVDT DDTSSENTVV PPETYVKVAG HLRSFQNKKS LVAFKIMPLE DMNEFTTHIL EVINAHMVLS KANSQPSAGR APISNPGMSE AGNFGGNSFM PANGLTVAQN QVLNLIKACP RPEGLNFQDL KNQLKHMSVS SIKQAVDFLS NEGHIYSTVD DDHFKSTDAE
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