About Erythroid transcription factor
Erythroid transcription factor (GATA1) is a protein
from Homo sapiens identified by UniProt accession
P15976, 413 residues long.
MolForge cross-references it against 0 known binders and
590 disease associations.
Target properties
| Protein name | Erythroid transcription factor |
|---|
| UniProt accession | P15976 |
|---|
| Gene | GATA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 413 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (590)
Diseases linked to this target (Open Targets).
- thrombocytopenia, X-linked, with or without dyserythropoietic anemia · score 0.78
- X-linked dyserythropoetic anemia with abnormal platelets and neutropenia · score 0.75
- Diamond-Blackfan anemia · score 0.71
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.65
- GATA1-Related X-Linked Cytopenia · score 0.64
- Beta-thalassemia - X-linked thrombocytopenia · score 0.62
- Thrombocytopenia · score 0.60
- Blackfan-Diamond anemia · score 0.58
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.52
- acute megakaryoblastic leukemia in down syndrome · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15976-F1 | alphafold | PREDICTED | 58.40 | — |
Amino-acid sequence (413 residues)
MEFPGLGSLG TSEPLPQFVD PALVSSTPES GVFFPSGPEG LDAAASSTAP STATAAAAAL AYYRDAEAYR HSPVFQVYPL LNCMEGIPGG SPYAGWAYGK TGLYPASTVC PTREDSPPQA VEDLDGKGST SFLETLKTER LSPDLLTLGP ALPSSLPVPN SAYGGPDFSS TFFSPTGSPL NSAAYSSPKL RGTLPLPPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRLIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD GIQTRNRKAS GKGKKKRGSS LGGTGAAEGP AGGFMVVAGG SGSGNCGEVA SGLTLGPPGT AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TGSFPTGPMP PTTSTTVVAP LSS
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